Enabling Cutting-Edge Technologies That Will Help Shape Our Future
2123 Frontiers uses our research, experts, and gatherings to take a systems approach to “enable” current cutting-edge technologies in science, engineering, medicine and technology.
Defining a frontier or breakthrough is no easy feat, but at its core, we believe these are “significant” advancements with the potential to create a positive impact on humanity. Honestly, some of them will work, and many may not. Some will be quick; some will take decades. The most important thing is to have the aspiration to change the trajectory of societal impact.
We believe this magic happens at the intersection of science, medicine, business, and engineering, driven by leaders who have the boldness, resilience, and persistence to push the envelope on new frontiers and drive breakthroughs!! Our platform brings together driven entrepreneurs, innovators, pioneers, and visionaries, all with a common purpose — “enabling” breakthroughs as we collectively push society’s frontiers.
Our Frontiers
Healthcare & Life Sciences
The pace of medical innovation continues to accelerate with new ideas being pursued. Scientists are focused on several major areas of unmet need from rare diseases (Huntington’s disease, sickle cell anemia) to neurological conditions (Alzheimer's, Parkinson's, Epilepsy) to oncology (pancreatic cancer, lung cancer, colorectal cancer) and metabolic health (diabetes, obesity, hormonal conditions).
Scientists have been making significant progress on many new tools and foundational capabilities e.g. gene editing, pharmacogenomics, personalized medicine, predictive analysis, novel biomarkers, implantable/wearable devices, tissue cell engineering. These new diagnostics, devices, drugs, and software/AI will allow us to better tackle some of the most impactful diseases in medicine.
We want to enable innovators, scientists, physicians, investors and entrepreneurs to accelerate the pace of medical innovation for humanity.
High Tech
Solutions that improve data structure, data architecture models, and data related technologies such as generative AI, large language models, cloud-native data, real time data processing are foundational.
Advancement in computation such as hardware advancement (quantum computing, semiconductors), software, and algorithms (high performance computing, quantum algorithms) are enabling the processing of larger amounts of data.
Spatial computing, Augmented reality (AR), Virtual reality (VR) and mixed reality is considered the next big paradigm shift in computing, enabling human-computer interaction to take place in the real world, in and around natural bodies and physical environments.
Innovations in robotics such as soft robotics, autonomous systems, human-robot interactions, bio-inspired robotics and AI and robotics integration have wide-ranging applications in a variety of industries such as healthcare, manufacturing, education.
To enable the secure implementation of technology, advances in cybersecurity tools such as zero trust architecture, next generation cloud workforce protection, password-less authentication, blockchain, quantum computing as well as ethical and legal guidelines must be put into place.
All these innovations will contribute to transformation in every industry and bringing us closer to a reality once only imagined!
Company Spotlight: Augmenteum
Overview: Augmenteum is on a mission to enable mass adoption of mixed reality head-mounted displays (HMDs) and smart glasses in a variety of applications. The company’s patented active optics technology solves for current issues with HMDs and smart glasses such as limited Field of Vision (FoV), the accomodation-convergence gap and motion blur/jitter. Augmenteum aspires to out-license the technology after developing a prototype.
Leadership: Anand Krishnamurthy, CEO; David Palacios, CTO
Financials: Current investments ($1.5M), including investments by TiE Boston Angels, Launchpad Ventures, Sidecar and Beacon Venture Partners.
Key Milestones: Prototype of Adaptive Optics Subsystem completed in two phases in April and July 2025, patent granted for SYSTEM FOR AND METHOD OF PROJECTING AUGMENTATION IMAGERY IN A HEAD-MOUNTED DISPLAY through 2035.
Recent Highlights: Successful completion of electrode pattern etching.
Forward Looking: Complete prototyping all phases in the next 4 months and out-license the technology to large technology partner in 2026.